Isotretinoin is an oral medication used for the treatment and prevention of serious acne. It is a highly effective systemic medication used to deal with serious recalcitrant nodular acne or inflammatory acne. It is categorized as a retinoid, made out of an artificial type of vitamin A.

This medication tackles severe inflammatory acne, cystic acne or scars especially if prescription medication like antibiotics become ineffective.

It is a highly effective prescription medication that is only reserved as an alternative to other unsuccessful treatment options. It is an oral medication (capsule) taken once or twice each day.

It is one of the most successful treatments available for patients with extreme comedonal acne or nodular cystic acne. Released research from the Journal of the American Academy of Dermatology showed that 69% to 75% of people who finished the isotretinoin medication course experienced a substantial reduction in acne breakout and some a total remission of acne.

The choice to begin using this type of medication is something you should discuss with your dermatologist, physician or health professional. Mainly because of its effectiveness and possible serious side effects. In fact, all patients using this drug are kept under cautious monitoring by their medical doctors or health-care professionals.

Isotretinoin Side Effects:

This potent oral acne medication may typically cause adverse reaction like dry nose, lips, mouth, eyes and skin as well as muscle aches, nosebleeds, itchiness, poor night vision and sun sensitivity.

The prescription could increase the degree of triglycerides and cholestrerol levels in the blood and may also raise liver enzyme levels.

It is linked to critical birth defects, therefore it cannot be safely used by expectant women or women that may possibly become pregnant over the course of treatment or within a few months of final treatment.

The fact is, the drug has such severe possible side effects that females of reproductive age have to take part in a Food and Drug Administration – approved tracking program to get a doctor’s prescription for the drug.

Furthermore, it may be connected with an increased chance of depressive disorder and committing suicide. Even though this causal connection has not been proven, medical practitioners continue to be alert for these symptoms in individuals who are using the drug.

If you are feeling very unhappy, or struggling to cope with the use of this medicine, inform your physician instantly.

Isotretinoin Systemic Treatment and the Ocular Adverse Effects

Prescription Drug linked to the Risk of Developing Eye Problems!

A research was conducted to establish how frequent eye complications developed among isotretinoin patients. The analysts gathered information on users and non-users for a more broader perspective.

Gabriel Chodick, PhD, a researcher at Tel Aviv University obtained the data from the electronic medical databases of a large health maintenance organisation in Israel on 14,682 young adults.

The study of the patients consisted of:

  1. First time teenage users of Isotretinoin for acne

Two age- and gender-matched comparison groups:

  1. Acne sufferers not on the medication
  2. Patients that were Acne free

The following findings were reported:

  • 13.8% of group A experienced ocular adverse effects versus 9.6% of group B and 7.1% of group C.
  • The most common ocular diagnoses were blepharitis, chalazion, conjunctivitis and hordeolum.
  • In comparing group A with group C, throughout a one year follow-up time period. Group A had experienced a significantly greater risk for any ocular adverse effects.
  • The increased risk of group A versus group B and group C started immediately from the first month and continued throughout the year, with a peak hazard at approximately four months after the index date.
  • No increased risk was observed in group B.
  • Group A had higher relative risks for inflammatory and structural adverse effects.

In summary the use of Isotretinoin may be connected with short-term ocular effects, particularly conjunctivitis, also called pink eye.

Hence, the significance of educating affected individuals and health care providers about the potentially adverse effects of this potent prescription drug.

Generic Name – Isotretinoin – since 2002

Brand Names






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